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A key component in this signaling cascade is phospholipase C (PLC), a crucial enzyme that, according to some scientific hypotheses, may facilitate the production of inositol triphosphate (IP3) and diacylglycerol (DAG)

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This approach could theoretically prevent Cas9 DNA integration into the host genome, thereby reducing the risk of unintended off-target effects and further enhancing the safety of LNP-based in vivo genome editing